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As expected, Ohio State will tip off with Duke at Cameron Indoor Arena on Wednesday, November 28th, 2012 on ESPN. The Buckeyes travel to the hallowed grounds having never previously played there. Ohio State defeated Duke 85-63 in 2011 at Value City Arena in Columbus. After having never won the competition from 1999 until 2008, the Big Ten broke through by winning 6-5 in 2009, following it up with another 6-5 victory in 2010, and an impressive 8-4 win in 2011. The league looks to make it four in a row with match ups as follows:
| Date | Game |
| Tue, Nov 27 | No. 13 North Carolina at No. 1 Indiana |
| No. 6 NC State at No. 5 Michigan | |
| No. 25 Minnesota at Florida State | |
| Maryland at Northwestern | |
| Iowa at Virginia Tech | |
| Nebraska at Wake Forest | |
| Wed, Nov 28 | No. 8 Ohio State at No. 15 Duke |
| Virginia at No. 22 Wisconsin | |
| No. 9 Michigan State at Miami | |
| Purdue at Clemson | |
| Georgia Tech at Illinois | |
| Boston College at Penn State |